Lipingshu capsule improves atherosclerosis associated with lipid regulation and inflammation inhibition in apolipoprotein E-deficient mice

文献类型： 外文期刊

第一作者： Xu, Jiqu

作者： Xu, Jiqu;Ma, Congcong;Chen, Meng;Huang, Fenghong;Xu, Jiqu;Ma, Congcong;Chen, Meng;Huang, Fenghong;Xu, Jiqu;Ma, Congcong;Chen, Meng;Huang, Fenghong;Rong, Shuang;Gao, Hui;Xia, Zumeng;Xia, Zumeng

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关键词： Lipingshu; Capsule; Atherosclerosis; Lipid profile; Inflammation

期刊名称：LIPIDS IN HEALTH AND DISEASE （ 影响因子：3.876； 五年影响因子：4.047 ）

ISSN： 1476-511X

年卷期： 2018 年 17 卷

页码：

收录情况： SCI

摘要： Background: Atherosclerosis (AS) is mainly responsible for cardiovascular diseases. The present study investigated whether Lipingshu capsule (LPS), whose ingredients are present in health food stores, has beneficial effect on AS. Methods: C57BL/6 J mice were given a low fat rodent diet and assigned as control group (CON). ApoE(-/-) mice were placed on high fat rodent diet and randomly separated into high fat diet (HFD) group and HFD + LPS group whose animals were given 0.9 g/kg.BW LPS daily for 10 weeks. Atherosclerotic lesions in aorta and aortic root were evaluated. Serum lipids and multiple cytokine were measured. Results: ApoE(-/-) mice fed with high fat diet had serious aortic lesions, whereas LPS markedly decreased plaque area of the total aorta and of the aortic root. LPS recovered the serum lipid profiles by substantially reducing TC, LDL-C, TG and Ox-LDL contents. Multi-cytokine analysis revealed greater serum levels of IL-l alpha, IL-1 beta, IL-6, IFN-gamma, GMCSF, RANTES and TNF-a induced by high fat diet slumped with LPS treatment. Conclusion: LPS reduces atherosclerotic lesions and thus alleviates AS by lipid profile modulation and inflammation inhibition.

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