Toxicokinetics of HT-2 Toxin in Rats and Its Metabolic Profile in Livestock and Human Liver Microsomes

文献类型： 外文期刊

第一作者： Yang, Shupeng

作者： Yang, Shupeng;Zhou, Jinhui;Li, Yi;Sun, Feifei;Yang, Shupeng;Zhou, Jinhui;Li, Yi;Sun, Feifei;Yang, Shupeng;Zhang, Huiyan;De Boevre, Marthe;Zhang, Jinzhen;De Saeger, Sarah;Yang, Shupeng;Zhang, Huiyan;Zhang, Suxia;Sun, Feifei;Li, Yanshen

作者机构：

关键词： bioavailability; metabolism; phenotype; mycotoxin; risk assessment

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2018 年 66 卷 30 期

页码：

收录情况： SCI

摘要： The lack of information on HT-2 toxin leads to inaccurate hazard evaluations. In the present study, toxicokinetic studies of HT-2 toxin were investigated following intravenous (iv) and oral administration to rats at dosages of 1.0 mg per kilogram of body weight. After oral administration, HT-2 toxin was not detected in plasma, whereas its hydroxylated metabolite, 3'-OH HT-2 was identified. Following iv administration, HT-2 toxin; its 3'-hydroxylated product; and its glucuronide derivative, 3-G1cA HT-2, were observed in plasma, and the glucuronide conjugate was the predominant metabolite. To explore the missing HT-2 toxin in plasma, metabolic studies of HT-2 toxin in liver microsomes were conducted. Consequently, eight phase I and three phase II metabolites were identified. Hydroxylation, hydrolysis, and glucuronidation were the main metabolic pathways, among which hydroxylation was the predominant one, mediated by 3A4, a cytochrome P450 enzyme. Additionally, significant interspecies metabolic differences were observed.

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