Immunological responses in haemolymph and histologic changes in the hepatopancreas of Charybdis japonica (A. Milne-Edwards, 1861) (Decapoda: Brachyura: Portunidae) exposed to bisphenol A

文献类型： 外文期刊

第一作者： Peng, Yan Qing

作者： Peng, Yan Qing;Wang, Meng Jie;Chen, Jian Hua;Gao, Huan;Peng, Yan Qing;Chen, Hai Gang;Chen, Jian Hua;Huang, Hong Hui;Peng, Yan Qing;Wang, Meng Jie;Chen, Jian Hua;Gao, Huan;Chen, Jian Hua;Wang, Meng Jie;Chen, Jian Hua;Gao, Huan

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关键词： endocrine-disrupting chemicals; immunity-related indicators; ultrastructure

期刊名称：JOURNAL OF CRUSTACEAN BIOLOGY （ 影响因子：1.43； 五年影响因子：1.501 ）

ISSN： 0278-0372

年卷期： 2018 年 38 卷 4 期

页码：

收录情况： SCI

摘要： Immunity-related indicators in the haemolymph and hepatopancreas were studied to investigate the toxic effects of bisphenol A (BPA) on the crabs Charybdis japonica (A. Milne-Edwards, 1861). These included total hemocyte counts (THC), the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), lysozyme (LSZ), phenoloxidase (PO), and the histological structure of the hepatopancreas. The results showed that THC declined at first and then gradually increased after exposure to different concentrations of BPA, and the activities of SOD, CAT, GPx, LSZ, and PO increased at first and then decreased. MDA, however, gradually increased over time following the exposure. The rough endoplasmic reticulum of hepatopancreas cells appeared swollen and reduced in number. Simultaneously, vacuoles, lysosomes, and myeloid bodies (MD) were observed in the hepatopancreas cells. These results indicate that BPA can affect the activities of immunity-related enzymes as well the histological structure of the hepatopancreas, which may be used as biomarkers of BPA in contaminated aquatic ecosystems.

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