Silver Inlaid with Gold Nanoparticles: Enhanced Antibacterial Ability Coupled with the Ability to Visualize Antibacterial Efficacy

文献类型： 外文期刊

第一作者： Li, Qing

作者： Li, Qing;Lu, Fei;Ye, Hongli;Yu, Kun;Lu, Bitao;Dai, Fangyin;Lan, Guangqian;Lu, Fei;Dai, Fangyin;Lan, Guangqian;Bao, Rong;Xiao, Yang

作者机构：

关键词： Alloy nanoparticles; Visualization; Fluorescence; Egg white; Nontoxic; Antimicrobial agent

期刊名称：ACS SUSTAINABLE CHEMISTRY & ENGINEERING （ 影响因子：8.198； 五年影响因子：8.471 ）

ISSN： 2168-0485

年卷期： 2018 年 6 卷 8 期

页码：

收录情况： SCI

摘要： Silver nanoparticles (Ag NPs) are widely used against bacteria, but further applications are restricted by their cytotoxicity. Their antibacterial efficiency cannot be measured because of the risk of development of multidrug resistance (MDR) with use of antibiotics. An alloy nanostructure of gold nanoparticles (Au NPs) inlaid on Ag NPs was synthesized using egg white protein (denoted here as Au-Ag NPs), exhibiting an enhanced antibacterial effect and can visually indicate the antibacterial efficacy by fluorescence. Interestingly, the fluorescence recovered after antibacterial action. Au-Ag NPs showed enhanced antibacterial effect, due to higher reactive oxygen species (ROS) generation than Ag NPs, after adhering to the surface of bacteria, suggesting that the silver content in Au-Ag NPs can be tuned to reach high antibacterial activity with low cytotoxicity. Au-Ag NPs visualized bacteria by fluorescence changes, which makes the antibacterial process clear and allows the dosage of antibacterial agents to be controlled accurately, which can prevent MDR Efficient antibacterial activity coupled with the ability to visualize bacterial processes allow Au-Ag NPs to be a potential solution in medicine and biosensing.

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