Preparation and Characterization of Size-Controlled Nanoparticles for High-Loading lambda-Cyhalothrin Delivery through Flash Nanoprecipitation

文献类型： 外文期刊

第一作者： Chen, Kai

作者： Chen, Kai;Fu, Zhinan;Wang, Mingwei;Guo, Xuhong;Chen, Kai;Lv, Yin;Guo, Xuhong;Wang, Chunxin;Shen, Yue;Wang, Yan;Cui, Haixin

作者机构：

关键词： flash nanoprecipitation; nanosuspension; lambda-cyhalothrin; block polymer

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2018 年 66 卷 31 期

页码：

收录情况： SCI

摘要： Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of lambda-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEGPDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.

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