Three unusual hybrid sorbicillinoids with anti-inflammatory activities from the deep-sea derived fungus Penicillium sp. SCSIO06868

文献类型： 外文期刊

第一作者： Pang, Xiaoyan

作者： Pang, Xiaoyan;Liao, Shengrong;Zhou, Xuefeng;Lin, Xiuping;Yang, Bin;Tian, Xinpeng;Wang, Junfeng;Liu, Yonghong;Wang, Pei;Pang, Xiaoyan;Liao, Shengrong;Zhou, Xuefeng;Lin, Xiuping;Yang, Bin;Tian, Xinpeng;Liu, Yonghong

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关键词： Penicillium sp. SCSIO06868; Aspergillaceae; Deep-sea derived fungus; Sorbicillinoids; Anti-inflammatory activities; Molecular networking

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.004； 五年影响因子：4.129 ）

ISSN： 0031-9422

年卷期： 2022 年 202 卷

页码：

收录情况： SCI

摘要： Under the guidance of MS/MS based molecular networking, bisorbicillchaetones A-C, three undescribed hybrid sorbicillinoids, were isolated from cultures of the deep-sea derived fungus Penicillium sp. SCSIO06868. The planar structures and absolute configurations of these compounds were determined by extensive spectroscopic analyses. Bisorbicillchaetones are the first examples of hybrid sorbicillinoids containing a coniochaetone unit. Bisorbicillchaetones A and B exhibited moderate inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC50 values of 80.3 +/- 3.6 mu M and 38.4 +/- 3.3 mu M, respectively, without cytotoxicity observed.

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