文献类型： 外文期刊
第一作者： Mei, Wei-Li
作者： Mei, Wei-Li;Dai, Hao-Fu;Yang, Hong -Run;Wang, Hao;Wang, Pei;Liu, Fang-Zheng;Chai, Hong-Xing;Cai, Cai-Hong;Yang, Li;Yuan, Jing-Zhe;Mei, Wei-Li;Dai, Hao-Fu;Yang, Hong -Run;Liu, Fang-Zheng;Chai, Hong-Xing;Jiang, Bei;Dai, Hao-Fu
作者机构：
关键词： Aquilaria filaria; Thymelaeaceae; 2-(2-Phenethyl)chromone dimers; Anti-inflammatory activity; Philippines
期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0031-9422
年卷期： 2024 年 222 卷
页码：
收录情况： SCI
摘要： Twelve undescribed 2-(2-phenethyl)chromone dimers ( 1 - 12 ) were isolated from EtOAc extract of agarwood originating from Aquilaria filaria in the Philippines, guided by a UHPLC-MS analysis. Their structures were elucidated by 1D NMR, 2D NMR, and HR-ESI-MS spectra. The absolute configuration of 2-(2-phenylethyl) chromone dimers was determined by single-crystal X-ray diffraction analysis and comparison of the experimental and calculated ECD spectra. Compounds 1 , 2 , 5 and 9 - 12 exhibited potent to moderate anti-inflammatory activity with IC 50 values in the range of 22.43 +/- 0.86 to 53.88 +/- 4.06 mu M.
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