Growth arrest and DNA damage inducible 45-beta activates pro-inflammatory cytokines and phagocytosis in the grass carp (Ctenopharyngodon idella) after Aeromonas hydrophila infection
文献类型： 外文期刊
第一作者： Bai, Yulin
作者： Bai, Yulin;Shen, Yubang;Xu, Xiao-yan;Bai, Yuqi;Fang, Yuan;Zhang, Meng;Miao, Yiheng;Zhang, Xueshu;Li, Jia-le;Shen, Yubang;Li, Jia-le;Shen, Yubang;Xu, Xiao-yan;Li, Jia-le;Shen, Yubang;Xu, Xiao-yan
作者机构：
关键词： Gadd45B; Grass carp; Innate immune response; Phagocytosis
期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）
ISSN： 0145-305X
年卷期： 2018 年 87 卷
页码：
收录情况： SCI
摘要： Growth arrest and DNA damage inducible 45-beta (Gadd45B) is essential for mitogen-activated protein kinases (MAPK) activities, and involved in regulating growth, apoptosis, and DNA demethylation. In the present study, the cDNA of gcGadd45Ba and geGadd45Bb in grass carp was identified. And the expression levels show that they were widely distributed in the tested tissues and showed significant immune responses both in vitro and in vivo after challenge with bacteria and pathogen-associated molecular patterns (PAMPs). Overexpression of Gadd45B significantly induced the expression of pro-inflammatory cytokines (IL-1 beta, IL-8, and INF-alpha) and enhanced the phagocytosis activation of grass carp blood cells. These results indicate that Gadd45B plays an important role in innate immune responses.
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