Highly Stable and NIR Luminescent Ru-LPMSN Hybrid Materials for Sensitive Detection of Cu2+ in Vivo

文献类型： 外文期刊

第一作者： Chen, Fangman

作者： Chen, Fangman;Zhang, Weibing;Xiao, Fangnan;Wu, Yunkun;Chen, Fangman;Zhang, Weibing;Lin, Chentao

作者机构：

关键词： ruthenium complex; LPMSN; Cu2+; in vivo

期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.229； 五年影响因子：9.57 ）

ISSN： 1944-8244

年卷期： 2018 年 10 卷 32 期

页码：

收录情况： SCI

摘要： Herein, new near-infrared (NIR) luminescent ruthenium complexes were prepared for detecting Cu2+ ions. Then, ruthenium complex hybrid nanomaterials (Ru-LPMSNs) were fabricated successfully by imbedding the ruthenium complex into mesoporous silica nanoparticles. Benefiting from the novel large-pore mesoporous structure and good adsorbility of LPMSNs, Ru-LPMSN hybrid materials showed a significantly enhanced fluorescence intensity and stability. NIR fluorescence of Ru LPMSNs was rapidly quenched by Cu2+ ions. Ru LPMSNs also showed high Cu2+ ion selectivity and sensitivity as a sensor. The detection limit of Cu2+ ions was 10 nM with a wide linear relationship between the fluorescence intensity of Ru LPMSNs and the concentration of Cu2+ ions. The mechanism of fluorescence quenching might be that the combination of the ruthenium complex and Cu2+ ions constrained the photoinduced electron-transfer process. Furthermore, Ru LPMSNs dramatically increased the fluorescence signals in cells and achieved Cu2+-ion detection. Ru LPMSNs had different tissue affinities and could monitor distribution of exogenous Cu2+ ions in vivo. Moreover, Ru LPMSNs realized direct and rapid detection of Cu2+-ion content in serum. These results indicated the potential applications of the prepared nanomaterials as Cu2+ detection agents.

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