Foot-and-mouth disease virus non-structural protein 2B negatively regulates the RLR-mediated IFN-beta induction

文献类型： 外文期刊

第一作者： Li, Ming

作者： Li, Ming;Xin, Ting;Gao, Xintao;Wu, Jing;Wang, Xixi;Fang, Lichun;Sui, Xiukun;Zhu, Hongfei;Cui, Shangjin;Guo, Xiaoyu;Wu, Jing;Sui, Xiukun

作者机构：

关键词： Foot-and-mouth disease virus; Protein 2B; Evasion; Innate immune; Type I IFNs

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2018 年 504 卷 1 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease virus (FMDV) is the causative agent of Foot-and-mouth disease (FMD), which is an acute and highly contagious disease affecting pigs, cattle and other cloven-hoofed animals. Several studies have shown that FMDV has evolved multiple strategies to evade the host innate immune response, but the underlying mechanisms for immune evasion are still not fully understood. In the current research, we have demonstrated that FMDV utilizes its non-structural protein 2B to sabotage the host immune response. Over-expression of the FMDV 2B inhibited Poly(1:C)-induced or SeV-triggered up-regulation of IFN-beta, IL-6 as well as ISG15. When HEK293T cells were transfected with FMDV 2B, the phosphorylation of TBK1 and IRF3 was inhibited. Co-immunoprecipitation and pull-down experiments indicated that FMDV 2B protein could interact with host RIG-I and MDA5. Moreover, FMDV 2B also inhibited the expression of the RIG-I and MDA5. Thus, FMDV 2B negatively regulates the RLR-mediated IFN-beta induction by targeting RIG-I and MDA5. (C) 2018 Elsevier Inc. All rights reserved.

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