Mulberry (Morus atropurpurea Roxb.) leaf polyphenols inhibits adipogenesis and lipogenesis-related gene expression in 3T3-L1 adipocytes

文献类型： 外文期刊

第一作者： Li, Qian

作者： Li, Qian;Dai, Yanli;Zou, Yuxiao;Liao, Sentai;Shen, Weizhi;Hu, Tenggen;Liu, Fan

作者机构：

关键词： 3T3-L1 adipocytes; antiobesity; lipid accumulation; Morus atropurpurea Roxb; Mulberry leaf polyphenols

期刊名称：JOURNAL OF FOOD BIOCHEMISTRY （ 影响因子：2.72； 五年影响因子：2.543 ）

ISSN： 0145-8884

年卷期： 2018 年 42 卷 5 期

页码：

收录情况： SCI

摘要： The effects of mulberry leaf polyphenols (MLPs) on the proliferation and differentiation of 3T3-L1 preadipocytes were investigated in this study. No significant inhibitory effect on cell proliferation when MLP content was 10-50 g/mL. MLP inhibited lipid accumulation in 3T3-L1 preadipocytes dose-dependently at concentrations of 0-50 g/mL. The treatment of differentiating 3T3-L1 cells with MLP at concentration of 40-50 g/mL significantly inhibited the spillage of free fatty acids (FFAs), reduced the intracellular total triglyceride (TG) and cholesterol (TC) concentration. Furthermore, a decrease in mRNA expression of peroxisome proliferator activated receptor- and CCAAT-enhancer-binding protein-, as well as fatty acid synthase and adiponectin were observed. This is the first study to demonstrate that MLP attenuated adipogenesis-related mRNA expression of 3T3-L1 preadipocytes. The findings suggested that MLP has complimentary potency for the regulation of obesity. Practical application The effects of MLP on the proliferation and differentiation of 3T3-L1 preadipocytes were investigated for the first time in this study. MLP decreased FAA, TC, TG, lipid accumulation and attenuated adipogenesis-related mRNA expression in differentiating 3T3-L1 cells. The result clearly identified mulberry leaf supplements could be used as a nutraceutical agent to ameliorate obesity and its complications

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