Enantioselective Acute Toxicity and Bioactivity of Carfentrazone-ethyl enantiomers

文献类型： 外文期刊

第一作者： Duan, Jinsheng

作者： Duan, Jinsheng;Gao, Beibei;Zhang, Zhaoxian;Wang, Minghua;Duan, Jinsheng;Sun, Mingna;Shen, Yang;Gao, Tongchun

作者机构：

关键词： Carfentrazone-ethyl; Chiral pesticides; Acute toxicity; Bioactivity; Molecular simulation

期刊名称：BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY （ 影响因子：2.151； 五年影响因子：2.129 ）

ISSN： 0007-4861

年卷期： 2018 年 101 卷 5 期

页码：

收录情况： SCI

摘要： The stereoselective herbicidal bioactivity and toxicity toward aquatic organisms of carfentrazone-ethyl enantiomers were investigated. The results showed that there was significant enantioselective acute toxicity toward Selenastrum bibraianum. In addition, S-(-)-carfentrazone-ethyl was 4.8 times more potent than R-(+)-isomer. However, a slight enantioselectivity was observed for Daphnia magna and Danio rerio. The stereoselective herbicidal bioactivity of carfentrazone-ethyl enantiomers was observed by assessing maize root-length inhibition. The results clarified that S-(-)-carfentrazone-ethyl (EC50 1.94mg/L)>Rac-carfentrazone-ethyl (EC50 2.18mg/L)>R-(+)-carfentrazone-ethyl (EC50 3.96mg/L). The herbicidal bioactivity of S-(-)-carfentrazone-ethyl was 2 times higher more than R-(+)-isomer. The mechanism of enantioselective bioactivity was illustrated using molecular simulation software. The GlideScore energies of S-(-)-carfentrazone-ethyl and R-(+)-carfentrazone-ethyl were -6.15kcal/mol and -5.59kcal/mol, indicating that the S-form has a greater affinity to the active site of protoporphyrinogen oxidase, which is consistent with the results of the bioactive assay. This study can rise the significance of risk assessments for carfentrazone-ethyl herbicide.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序