Identification and characterization of microRNAs in white and black coated yak

文献类型： 外文期刊

第一作者： Basang, Wang-Dui

作者： Basang, Wang-Dui;An, Tian-Wu;Luo, Xiao-Lin;Zhu, Yan-Bin;Danjiu, Luo-Bu;He, Shi-Cheng;E, Guang-Xin;An, Tian-Wu;Luo, Xiao-Lin;Danjiu, Luo-Bu;He, Shi-Cheng;E, Guang-Xin

作者机构：

关键词： MicroRNA; RNA-seq; Target gene; Coat color; Yak

期刊名称：INDIAN JOURNAL OF ANIMAL RESEARCH （ 影响因子：0.44； 五年影响因子：0.543 ）

ISSN： 0367-6722

年卷期： 2018 年 52 卷 6 期

页码：

收录情况： SCI

摘要： In this study, we used high-throughput technology to provide the first transcriptome dataset for differentially expressed miRNA in mixed pools of dermis tissue from black-and white-coated yak to research the possible molecular mechanisms of yak coat pigmentation. In this study, 92,636,002 and 95,917,842 clear reads were generated through Illumina paired-end sequencing. A total of 78 differentially expressed miRNAs (DEMs) were identified, including 59 upregulated and 19 downregulated miRNAs in the mixed pools of white-coated yak compared with the mixed pools of black-coated yak. In addition, 3634 genes were predicted as putative targets of DEMs. These DEGs related to 59 GO categories and were enriched in 216 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including melanogenesis and the Wnt signaling pathway. The results of the current study indicated that the coat color of the yak involved the transcriptional regulation process of miRNAs. These results provide helpful data to understand the molecular mechanisms of yak coat pigmentation.

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