Investigation of mitochondrial DNA genetic diversity and phylogeny of goats worldwide

文献类型： 外文期刊

第一作者： GUO, Yi

作者： GUO, Yi;HE, Yong-meng;YANG, Bai-gao;ZHANG, Wei-yi;HUANG, Yong-fu;E, Guang-xin;GONG, Ying;CHEN, Bo-er;ZHANG, Dan-ping;MA, Yue-hui;CHU, Ming-xing

作者机构： Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China;Chongqing Agr & Rural Affairs Comm Tongnan, Chongqing 402660, Peoples R China;Dazhou Anim Husb Technol Extens Stn, Dazhou 635299, Peoples R China;Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China

关键词： mitochondrial DNA; genetic diversity; population structure; population expansion; phylogeny

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 2021影响因子：4.384； 五年影响因子：4.021 ）

ISSN： 2095-3119

年卷期： 2022 年 21 卷 6 期

页码：

收录情况： SCI

摘要： Genetic diversity, population structure, and population expansion of goats worldwide (4 165 individuals from 196 breeds) were analyzed using published mitochondrial DNA (mtDNA) D_loop hypervariable region sequences. Results showed that 2 409 haplotypes and 301 polymorphic sites were present within the 401-bp length D_loop region, the nucleotide diversity (Pi) was 0.03471, and the haplotype diversity (Hd) was 0.9983. Phylogenetic analysis revealed that 98.92% of haplotypes were divided into six obvious clusters, consistent with the classification of the known mitochondrial haplogroups of goats. Haplogroup A accounted for the largest proportion (86%). Interestingly, two unknown divisions (Unknown I and Unknown II) were discovered from goats in Southwest China, suggesting that Southwest China has unique maternal haplogroups. Analysis of molecular variance (AMOVA) and the average number of pairwise differences between populations (PiXY) indicated that geographical variation was small but significant. Neutrality tests (Tajima's D and Fu's FS tests) and mismatch distribution showed that haplogroups B, C, and G had expansion histories. In addition, the phylogenetic relationship between domestic and wild goats suggested that Capra aegagrus is the most likely wild ancestor and may have participated in the domestication of ancestral populations of A, B, C, and F haplogroups. A meta-analysis on the mtDNA sequences of goats from international databases was conducted to analyze goats' genetic diversity, population structure, and matrilineal system evolution worldwide. The results may help further understand the

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