QTL Detection for Albinism-Related Loci in Chinese Tongue Sole (Cynoglossus semilaevis)

文献类型： 外文期刊

第一作者： Liu Yang

作者： Liu Yang;Xu Wenteng;Zhang Bo;Shao Changwei;Wang Xiaoxia;Sun Hejun;Wang Na;Chen Songlin;Liu Yang;Xu Wenteng;Zhang Bo;Shao Changwei;Wang Xiaoxia;Sun Hejun;Wang Na;Chen Songlin;Zhang Bo

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关键词： albinism; Cynoglossus semilaevis; locus mapping; simple sequence repeat

期刊名称：JOURNAL OF OCEAN UNIVERSITY OF CHINA （ 影响因子：0.913； 五年影响因子：1.012 ）

ISSN： 1672-5182

年卷期： 2018 年 17 卷 6 期

页码：

收录情况： SCI

摘要： The Chinese tongue sole (Cynoglossus semilaevis) is widely cultured in the coastal region of East Asia and has excellent economic value. However, the high albino rate of the breeding population has caused a significant loss to the aquaculture industry. To study the molecular mechanism of albinism, the present study used an albino Chinese tongue sole family to construct three simple sequence repeat (SSR) linkage groups, and draft a preliminary linkage map related to albinism. After albinism-related loci mapping, 18 albinism-related loci were detected under two models (containing 2407 genes) compared to the Chinese tongue sole genome. One of these loci, the tyrosinase related protein (tyrp2), which has been reported previously as an important gene regulating both eumelanin and phaeomelanin levels, was indicated to be the possible cause of albinism. Thirty-five Gene Ontology (GO) terms and 14 Kyoto Encyclopedia of Genes and Genome pathways were annotated via bioinformatic analyses. One GO term with protein tyrosine kinase activity, which contained 10 genes, was previously suggested to affect fish albinism. These results establish a foundation for further in-depth study of albinism in Chinese tongue sole.

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