The IMPDH inhibitors, ribavirin and mycophenolic acid, inhibit peste des petits ruminants virus infection

文献类型： 外文期刊

第一作者： Chang, Qiu-yan

作者： Chang, Qiu-yan;Guo, Fu-cheng;Pan, Qiuwei;Ma, Xiao-xia;Chang, Qiu-yan;Pan, Qiuwei;Ma, Xiao-xia;Li, Xue-rui;Zhou, Jian-hua;Cai, Xuepeng;Ma, Xiao-xia

作者机构：

期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：2.459； 五年影响因子：2.352 ）

ISSN： 0165-7380

年卷期： 2018 年 42 卷 4 期

页码：

收录情况： SCI

摘要： Peste des petits ruminants virus (PPRV) causes highly contagious diseases in domestic and particular wild small ruminants, leading to substantial economic loss. The development of effective and cheap antiviral medications shall help to circumvent this emerging burden. In this study, we found that ribavirin, a competitive inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor, significantly inhibits the replication of PPRV. As IMPDH is a key enzyme in purine nucleotide synthesis, supplementation of exogenous guanosine attenuate the anti-PPRV effect of ribavirin. Interestingly, an uncompetitive IMPDH inhibitor, mycophenolic acid (MPA), exerted more potent antiviral effect again PPRV. Similarly, this effect was largely restored upon supplementation of guanosine. Thus, we have demonstrated that the IMPDH inhibitors ribavirin and MPA combat PPRV infection through purine nucleotide depletion. Because both regimens have been widely used in the clinic for treating viral infection or organ rejection in transplantation patients for decades, respectively, repurposing these existing safe and cheap medications may provide a new avenue for combating PPRV infection.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序