Limonoids from the roots of Trichilia sinensis and their cytotoxicities

文献类型： 外文期刊

第一作者： Liu, Shou-Bai

作者： Liu, Shou-Bai;Mei, Wen-Li;Chen, Hui-Qin;Wang, Jun;Dai, Hao-Fu;Liu, Shou-Bai;Wang, Zhu-Nian

作者机构：

关键词： Trichilia sinensis; Roots; Trichilin-type limonoids; Cytotoxic activities

期刊名称：ARCHIVES OF PHARMACAL RESEARCH （ 影响因子：4.946； 五年影响因子：3.483 ）

ISSN： 0253-6269

年卷期： 2018 年 41 卷 12 期

页码：

收录情况： SCI

摘要： Six new compounds (1-4, 8, 10), along with six known limonoids (5-7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including H-1 NMR, C-13 NMR, DEPT, HSQC, HMBC, H-1-H-1 COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

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