Metabolites from the Paracel Islands Soft Coral Sinularia cf. molesta

文献类型： 外文期刊

第一作者： Chu, Mei-Jun

作者： Chu, Mei-Jun;Han, Xiao;Li, Tao;Luo, Xiang-Chao;Jiang, Ming-Ming;Li, Ping-Lin;Li, Guo-Qiang;Chu, Mei-Jun;Tang, Xu-Li;Han, Xiao;Li, Tao;Luo, Xiang-Chao;Jiang, Ming-Ming;Li, Ping-Lin;Li, Guo-Qiang;van Ofwegen, Leen;Luo, Lian-Zhong;Zhang, Gang

作者机构：

关键词： Marine soft coral; Sinularia; terpenoids

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2018 年 16 卷 12 期

页码：

收录情况： SCI

摘要： Five new oxygenated sesquiterpenes, molestins A-D (1, 3-5) and epi-gibberodione (2), three new cyclopentenone derivatives, ent-sinulolides C, D, and F ((+)-9-(+)-11), one new butenolide derivative, ent-sinulolide H ((+)-13), and one new cembranolide, molestin E (14), together with 14 known related metabolites (6-8, (-)-9-(-)-11, (+/-)-12, (-)-13, 15-19) were isolated from the Paracel Islands soft coral Sinularia cf. molesta. The structures and absolute configurations were elucidated based on comprehensive spectroscopic analyses, quantum chemical calculations, and comparison with the literature data. Compound 5 is the first example of a norsesquiterpene with a de-isopropyl guaiane skeleton isolated from the genus Sinularia. Molestin E (14) exhibited cytotoxicities against HeLa and HCT-116 cell lines with IC50 values of 5.26 and 8.37 M, respectively. Compounds 4, 5, and 8 showed significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 218, 344, and 1.24 M, respectively.

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