Effect of a novel antifungal peptide P852 on cell morphology and membrane permeability of Fusarium oxysporum

文献类型： 外文期刊

第一作者： Han, Yuzhu

作者： Han, Yuzhu;Zhang, Bao;Li, Pinglan;Han, Yuzhu;Zhao, Jianjun;Shang, Qingmao;Shen, Qian

作者机构：

关键词： Antifungal peptide; Fusarium oxysporum; Membrane permeabilization; Cell morphology

期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES （ 影响因子：3.747； 五年影响因子：4.404 ）

ISSN： 0005-2736

年卷期： 2019 年 1862 卷 2 期

页码：

收录情况： SCI

摘要： P852, a novel cyclic peptide isolated from Bacillus amyloliquefaciens L-H15, showed potent antifungal activity against several major plant fungal pathogens including Fusarium oxysporum. To elucidate the antifungal mechanism, the impact of P852 on the cell morphology and membrane permeabilization of F. oxysporum was studied. By applying electron microscopy and fluorescent techniques, we showed that P852 treatment caused the morphological change of F. oxysporum cells and disrupted its cell structure, including formation of blebs, broken hyphae, deformation of membrane, intracellular organization disruption, pore formation, and cell lysis. Our findings provide insights into the mode of action of P852, which laying a foundation to develop P852 as a novel antifungal agent to control plant fungal pathogens.

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