Molecular Mechanism of VSV-Vectored ASFV Vaccine Activating Immune Response in DCs

文献类型： 外文期刊

第一作者： Ma, Yunyun

作者： Ma, Yunyun;Shao, Junjun;Liu, Wei;Gao, Shandian;Zhou, Guangqing;Chang, Huiyun;Qi, Xuefeng

作者机构：

关键词： dendritic cells; antigen presentation; recombinant viruses; immune response; ASFV

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

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年卷期： 2025 年 12 卷 1 期

页码：

收录情况： SCI

摘要： The vesicular stomatitis virus (VSV)-vectored African swine fever virus (ASFV) vaccine can induce efficient immune response, but the potential mechanism remains unsolved. In order to investigate the efficacy of recombinant viruses (VSV-p35, VSV-p72)-mediated dendritic cells (DCs) maturation and the mechanism of inducing T-cell immune response, the functional effects of recombinant viruses on DC activation and target antigens presentation were explored in this study. The results showed that surface-marked molecules (CD80, CD86, CD40, and MHC-II) and secreted cytokines (IL-4, TNF-alpha, IFN-gamma) were highly expressed in the recombinant virus-infected DCs. In addition, the co-culture results of recombinant virus-treated DCs with naive T cells showed that the Th1- and Th17-type responses were effectively activated. Taken together, the study indicated that the VSV-vectored ASFV vaccine activated the maturation of DCs and the Th1- and Th17-type immune response, which provided a theoretical basis for the development of novel ASF vaccines.

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