Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo

文献类型： 外文期刊

第一作者： Xia, Xiaoyang

作者： Xia, Xiaoyang;Xiang, Xia;Huang, Fenghong;Zheng, Mingming;Zhang, Zhen;Han, Ling

作者机构：

关键词： Canolol; Apoptosis; ROS; Mitochondria; MAPK

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.192； 五年影响因子：4.61 ）

ISSN： 0009-2797

年卷期： 2019 年 300 卷

页码：

收录情况： SCI

摘要： Canolol (4-vinylsyringol), extracted form crude canola oil, is the promising drug toward cancer prevention and treatment. The current studies focus on the role of COX-2 signaling pathway in canolol-induced apoptosis in cancer cells. It is still unknown whether mitochondria and MAPK signaling pathways are involved. To elucidate the roles of above signaling pathways in canolol-induced apoptosis in cancer cells, human cervical carcinoma cell line HeLa and HeLa xenograft tumor model are adopted. Canolol induced apoptosis of HeLa cells and inhibited tumor growth with low systemic adverse effect, accompanying with excess generation of intracellular ROS and lysosome rupture. The results in vitro and in vivo confirmed that MAPK signaling pathways mediated mitochondrial signaling pathway activation were involved in canolol-induced apoptosis. In conclusion, these data showed that canolol induced apoptosis in HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway, providing a view of the potential application of canolol as an anticancer agent.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序