MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS

文献类型： 外文期刊

第一作者： Zhang, Chi

作者： Zhang, Chi;Li, Ningqiu;Fu, Xiaozhe;Lin, Qiang;Tu, Jiagang;Zhang, Chi;Lin, Li;Tu, Jiagang;Lin, Li;Tu, Jiagang

作者机构：

关键词： Nakehead vesiculovirus; microRNA; miR-214; Replication; Glycogen synthase

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）

ISSN： 1050-4648

年卷期： 2019 年 84 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) are small noncoding RNAs that have been reported to play important roles in virus replication. Snakehead vesiculovirus (SHVV) is a new rhabdovirus isolated from diseased hybrid snakehead and has caused heavy economical losses in cultured snakehead fish in China. Our previous study has revealed that miR-214 inhibited SHVV replication, but the underline mechanism was not completely understood. In this study, glycogen synthase (GS) gene was identified as a target gene of miR-214. Overexpression of miR-214 reduced cellular GS gene expression. Knockdown of GS by siRNA, similar to the overexpression of miR-214, inhibited SHW replication. Moreover, we found that siGS-mediated inhibition of SHVV replication could be restored by reducing cellular miR-214 level via using miR-214 inhibitor, indicating that miR-214 inhibited SHVV replication at least partially via targeting GS. This study provided information for understanding the molecular mechanism of SHVV pathogenicity and a potential antiviral strategy against SHW infection.

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