Natural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape

文献类型： 外文期刊

第一作者： Lin, Li

作者： Lin, Li;Zhang, Xingrui;Fan, Jialin;Ren, Sichao;Gu, Xin;Li, Panpan;Xu, Jingyi;Lei, Wenjing;Wang, Youping;Wu, Jian;Lin, Li;Xu, Meiling;Liu, Dongxiao;Sun, Qinfu;Wang, Youping;Li, Jiawei;Yang, Qing-Yong;Cai, Guangqin

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.7； 五年影响因子：16.1 ）

ISSN：

年卷期： 2024 年 15 卷 1 期

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收录情况： SCI

摘要： Sclerotinia stem rot (SSR), caused by the necrotrophic fungus Sclerotinia sclerotiorum, is one of the most devastating diseases for several major oil-producing crops. Despite its impact, the genetic basis of SSR resistance in plants remains poorly understood. Here, through a genome-wide association study, we identify a key gene, BnaA07. MKK9, that encodes a mitogen-activated protein kinase kinase that confers SSR resistance in oilseed rape. Our functional analyses reveal that BnaA07.MKK9 interacts with BnaC03.MPK3 and BnaC03.MPK6 and phosphorylates them at the TEY activation motif, triggering a signaling cascade that initiates biosynthesis of ethylene, camalexin, and indole glucosinolates, and promotes accumulation of H2O2 and the hypersensitive response, ultimately conferring resistance. Furthermore, variations in the coding sequence of BnaA07.MKK9 alter its kinase activity and improve SSR resistance by similar to 30% in cultivars carrying the advantageous haplotype. These findings enhance our understanding of SSR resistance and may help engineer novel diversity for future breeding of oilseed rape.

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