The nature and epidemiology of OqxAB, a multidrug efflux pump

文献类型： 外文期刊

第一作者： Li, Jun

作者： Li, Jun;Zhang, Heying;Ning, Jianan;Sajid, Abdul;Yuan, Zonghui;Hao, Haihong;Li, Jun;Zhang, Heying;Ning, Jianan;Sajid, Abdul;Yuan, Zonghui;Hao, Haihong;Li, Jun;Cheng, Guyue;Yuan, Zonghui;Hao, Haihong;Sajid, Abdul

作者机构：

关键词： oqxAB; Multidrug efflux pump; Quinoxalines; Quinolones; Tigecycline; Nitrofurantoin

期刊名称：ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL （ 影响因子：4.887； 五年影响因子：5.171 ）

ISSN： 2047-2994

年卷期： 2019 年 8 卷

页码：

收录情况： SCI

摘要： BackgroundOqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant.MethodsA literature search using the keyword of oqxAB was conducted in the online databases of Pubmed and ISI Web of Science with no restriction on the date of publication. The 87 publications were included into this review as references due to their close relevance to the nature and/or epidemiology of OqxAB efflux pump.ResultsThe oqxAB gene generally locates on chromosome and/or plasmids flanked by IS26-like elements in clinical isolates of Enterobacteriaceae and Klebsiella pneumoniae, conferring low to intermediated resistance to quinoxalines, quinolones tigecycline, nitrofurantoin, several detergents and disinfectants (benzalkonium chloride, triclosan and SDS). It could co-spread with other antimicrobial resistance genes (bla(CTX-M), rmtB and aac(6)-Ib etc.), virulence genes and heavy metal resistance genes (pco and sil operons). Both RarA (activator) and OqxR (repressor) play important roles on regulation of the expression of OqxAB.ConclusionsThe dissemination of oqxAB gene may pose a great risk on food safety and public health. Further investigation and understanding of the natural functions, horizontal transfer, and regulation mechanism of the OqxAB efflux pump will aid in future strategies of antimicrobial usage.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序