Isolation and characterization of duck adenovirus 3 circulating in China

文献类型： 外文期刊

第一作者： Shi, Shaohua

作者： Shi, Shaohua;Liu, Rongchang;Wan, Chunhe;Cheng, Longfei;Chen, Zhen;Fu, Guanghua;Chen, Hongmei;Fu, Qiuling;Huang, Yu;Shi, Shaohua;Liu, Rongchang;Wan, Chunhe;Cheng, Longfei;Chen, Zhen;Fu, Guanghua;Chen, Hongmei;Fu, Qiuling;Huang, Yu;Shi, Shaohua;Liu, Rongchang;Wan, Chunhe;Cheng, Longfei;Chen, Zhen;Fu, Guanghua;Chen, Hongmei;Fu, Qiuling

作者机构：

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2019 年 164 卷 3 期

页码：

收录情况： SCI

摘要： Recently, infectious disease outbreaks characterized by swelling and hemorrhagic liver and kidneys occurred in Muscovy ducklings in China. Four viruses were isolated and identified as adenoviruses by transmission electron microscopy (TEM) and polymerase chain reaction (PCR). Sequence analysis identified the new isolates as duck adenovirus 3 (DAdV-3), species Duck aviadenovirus B. The pathogenicity of the new isolate DAdV-3 FJGT01 was investigated using challenge experiments. The gross lesions in the animal experiment were similar to the clinical lesions observed in the diseased ducks. TEM examination of liver sample showed that virions accumulated and arranged in crystal lattice formations in the nuclei of hepatocytes. The present study provides new information about the epidemiology and characteristics of duck adenovirus associated with Muscovy ducklings.

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