The genetic basis of inbreeding depression in potato

文献类型： 外文期刊

第一作者： Zhang, Chunzhi

作者： Zhang, Chunzhi;Wang, Pei;Shang, Yi;Li, Canhui;Zhang, Chunzhi;Tang, Die;Huang, Sanwen;Zhang, Chunzhi;Huang, Sanwen;Yang, Zhongmin;Lu, Fei;Qi, Jianjian;Tawari, Nilesh R.

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：38.33； 五年影响因子：36.431 ）

ISSN： 1061-4036

年卷期： 2019 年 51 卷 3 期

页码：

收录情况： SCI

摘要： Inbreeding depression confers reduced fitness among the offspring of genetic relatives. As a clonally propagated crop, potato (Solanum tuberosum L.) suffers from severe inbreeding depression; however, the genetic basis of inbreeding depression in potato is largely unknown. To gain insight into inbreeding depression in potato, we evaluated the mutation burden in 151 diploid potatoes and obtained 344,831 predicted deleterious substitutions. The deleterious mutations in potato are enriched in the pericentromeric regions and are line specific. Using three F-2 populations, we identified 15 genomic regions with severe segregation distortions due to selection at the gametic and zygotic stages. Most of the deleterious recessive alleles affecting survival and growth vigor were located in regions with high recombination rates. One of these deleterious alleles is derived from a rare mutation that disrupts a gene required for embryo development. This study provides the basis for genome design of potato inbred lines.

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