Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzuspersicae

文献类型： 外文期刊

第一作者： Singh, Kumar Saurabh

作者： Singh, Kumar Saurabh;Troczka, Bartlomiej J.;Pym, Adam;Mackisack, Joanna;Duarte, Ana;Ffrench-Constant, Richard H.;Zimmer, Christoph T.;Hayward, Alex;Bass, Chris;Cordeiro, Erick M. G.;Mathers, Thomas C.;Legeai, Fabrice;Robin, Stephanie;Simon, Jean-Christophe;Bielza, Pablo;Burrack, Hannah J.;Charaabi, Kamel;Denholm, Ian;Figueroa, Christian C.;Ramirez, Claudio C.;Jander, Georg;Margaritopoulos, John T.;Mazzoni, Emanuele;Nauen, Ralf;Ren, Guangwei;Stepanyan, Ilona;Umina, Paul A.;Umina, Paul A.;Voronova, Nina V.;Vontas, John;Vontas, John;Williamson, Martin S.;Wilson, Alex C. C.;Gao Xi-Wu;Youn, Young-Nam;Zimmer, Christoph T.

作者机构：

期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：6.268； 五年影响因子：6.268 ）

ISSN：

年卷期： 2021 年 4 卷 1 期

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收录情况： SCI

摘要： Singh, Bass and colleagues generate new genomic resources for the aphid crop pest, Myzus persicae, comprising a chromosome-scale genome assembly and resequenced genomes of >100 globally sampled clonal lines. Using this dataset, they uncover both mechanisms underpinning the evolution of insecticide resistance and ecological factors that influence its emergence and spread. The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host-plant associations, uncovering the widespread co-option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.

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