Enzymatic Synthesis and Antioxidant Activity of 1-Caffeoylglycerol Prepared from Alkyl Caffeates and Glycerol

文献类型： 外文期刊

第一作者： Meng, Xiang-Yun

作者： Meng, Xiang-Yun;Xu, Yan;Wu, Jin-Xian;Zhu, Chang-Tong;Zhang, Dong-Yang;Wu, Guo-Hua;Wu, Fu-An;Wang, Jun;Meng, Xiang-Yun;Zhu, Chang-Tong;Wu, Guo-Hua;Wang, Jun;Xu, Yan;Zhang, Dong-Yang;Wu, Guo-Hua;Wu, Fu-An;Wang, Jun

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关键词： 1-Caffeoylglycerol; Enzymatic transesterification; Antioxidant capacity; Methyl caffeate; 1; 1-Diphenyl-2-picrylhydrazyl radical scavenging; -Carotene-linoleic acid assay

期刊名称：JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY （ 影响因子：1.849； 五年影响因子：2.299 ）

ISSN： 0003-021X

年卷期： 2018 年 95 卷 2 期

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收录情况： SCI

摘要： Caffeic acid (CA) as a strong antioxidant has lower solubility in nonpolar media, which limits its application in the food industry. To increase the lipophilicity of CA, 1-caffeoylglycerol (1-CG) was synthesized by lipase-catalyzed transesterification of alkyl caffeates in solvent-free system and its antioxidant capacity was investigated. Methyl caffeate was screened as the appropriate substrate from tested alkyl caffeates with a yield of 90.63%. Ethyl acetate was used for extracting 1-CG from enzymatic reactants and could be easily recycled. The produced 1-CG had 2.5- and 10-fold lower values of half maximal inhibitory concentration (IC50) (10.86 and 3.99M) than butylated hydroxyanisole by 1,1-diphenyl-2-picrylhydrazyl radical scavenging and -carotene-linoleic acid assays, respectively. Thus, 1-CG is an excellent antioxidant for application in the functional food industry. Using alkyl caffeates and glycerol as substrates to produce 1-CG catalyzed by immobilized lipase in a solvent-free system is a simple, selective, and safe bioprocess that can readily be achieved in the food industry, and the product 1-CG could be widely applied in food, nutraceutical, and biotechnological products.

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