Genome-wide association studies for two exterior traits in Chinese Dongxiang spotted pigs

文献类型： 外文期刊

第一作者： Wang, Chengbin

作者： Wang, Chengbin;Wang, Xiaopeng;Tang, Jianhong;Chen, Hao;Zhang, Junjie;Li, Yiping;Yang, Bin;Ren, Jun;Ding, Nengshui;Lei, Shengrong;Ji, Huayuan

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关键词： candidate genes; Chinese Dongxiang spotted pigs; facial type; GWAS; spotted coat color

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）

ISSN： 1344-3941

年卷期： 2018 年 89 卷 6 期

页码：

收录情况： SCI

摘要： Pigs show extensive variation in exterior appearance. This variation has been explored as one of the selection targets to form breeding features in the pig industry. In this study, a customized Affymetrix Axiom Pig1.4M array plate was used to conduct genome-wide association studies (GWAS) for two exterior traitsspotted coat color (SC) and facial type (FT)in Chinese Dongxiang spotted pigs. Two and 12 single nucleotide polymorphisms (SNPs) were identified to be associated with SC and FT at the 5% genome-wide significant level, respectively. Of these SNPs, two associated with SC were located around the DACH1 gene on Sus Scrofa chromosome (SSC)11. Eleven SNPs associated with FT were located within a 7.68Mb region (29.03-36.71Mb) on SSC7. Based on the GWAS results and the biological functions of genes, we highlight EDNRB as a candidate gene for SC and HMGA1 and RPS10 as the potential genes affecting facial variation. The findings contribute to the final characterization of causative genes and mutations underlying the effects of the SSC7 and SSC11 loci and improve our understanding of the genetic basis of phenotypic variation in Chinese indigenous pigs.

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