A novel targeted anticancer drug delivery strategy: Cnidium officinale polysaccharide conjugated with carboxymethyl-5-fluorouracil and folic acid for ovarian cancer therapy

文献类型： 外文期刊

第一作者： Zhang, Yutong

作者： Zhang, Yutong;Zhang, Yanjun;Zhang, Yutong;Palanisamy, Subramanian;Kwon, Mi-Hye;Kou, Fang;Uthamapriya, Rajavel Arumugam;Lee, Dongki;Lee, Dong-Jin;You, Sangguan;Palanisamy, Subramanian;Kwon, Mi-Hye;Uthamapriya, Rajavel Arumugam;You, Sangguan;Ge, Yunfei;Bao, Honghui;Bao, Honghui;Bao, Honghui

作者机构：

关键词： Polysaccharide; 5-fluorouracil; Folic acid; Anticancer; Drug deliver

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 285 卷

页码：

收录情况： SCI

摘要： To mitigate adverse reactions induced by 5-fluorouracil (5-FU), Cnidium officinale fraction 2 (F2) polysaccharides served as the macromolecular carrier, facilitating its reaction with carboxymethyl-5-fluorouracil (C-5-FU) for producing F2-C-5-FU. Subsequently, this compound could react with folic acid (FA) through the ester bond, forming F2-C-5-FU-FA, as verified through NMR analysis. The in vitro anticancer efficacy of F2-C-5-FU-FA was evaluated using SKOV-3 cells that expressed folate receptor (FR) and FR-deficient A549 cells, showing greater cytotoxicity in the SKOV-3 cell line due to the FRs on the cell membrane. In vivo experiments were conducted on SKOV-3-bearing xenograft mice using an in vivo imaging system (IVIS). Animals injected with F2-C-5-FU-FA exhibited significantly stronger targeting of tumor tissue compared to those injected with F2-C-5-FU. These findings highlighted enhanced drug delivery and accumulation in targeted tumor regions facilitated by folatetargeted conjugates. Moreover, F2-C-5FU-FA showed reduced cardiac toxicity in mice and minimal spleen accumulation, indicating a negligible effect on the immune system. Overall, this study introduced a novel strategy for achieving highly efficient anticancer drug delivery into tumor cells that express FR.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序