Developmental toxicity by thifluzamide in zebrafish (Danio rerio): Involvement of leptin

文献类型： 外文期刊

第一作者： Yang, Yang

作者： Yang, Yang;Dong, Fengshou;Liu, Xingang;Xu, Jun;Wu, Xiaohu;Zheng, Yongquan;Wang, Donghui

作者机构：

关键词： Thifluzamide; Zebrafish; Bone development; Lipid metabolism; cAMP-PKA-CREB-lep

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2019 年 221 卷

页码：

收录情况： SCI

摘要： Although previous trials have indicated that thifluzamide induces developmental inhibition in zebrafish, understanding the distinct mechanism of thifluzamide in this process remains challenging. This study investigated the effect of thifluzamide on zebrafish development and the underlying related signaling pathway. Thifluzamide repressed glucagon (GC) levels but increased growth hormone (GH) levels, and changed the expression of the genes related to growth and development. Additionally, protein kinase A (PKA) and leptin levels were obviously decreased in zebrafish after exposure to thifluzamide for 28 days, but the phosphorylation of CAMP responsive element-binding protein (CREB) was increased. Our results suggested that the anti-developmental effects of thifluzamide in zebrafish are largely associated with alterations in expressions of genes related to growth and development through modulation of leptin. (C) 2019 Elsevier Ltd. All rights reserved.

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