Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

文献类型： 外文期刊

第一作者： Qi, Zeng

作者： Qi, Zeng;Li, Zhuo;Li, Pingya;Liu, Jinping;Chen, Lixue;Shao, Zijun;Qi, Yuli;Gao, Kun;Liu, Songxin;Sun, Yinshi;Chen, Lixue;Shao, Zijun;Qi, Yuli;Gao, Kun;Liu, Songxin;Sun, Yinshi

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关键词： ginsenoside Rh-2; (24R)-pseudo-ginsenoside HQ; (24S)-pseudo-ginsenoside HQ; immunomodulatory; cyclophosphamide; immunosuppression; anti-tumor activity in vivo

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2019 年 20 卷 4 期

页码：

收录情况： SCI

摘要： (24R)-pseudo-ginsenoside HQ (R-PHQ) and (24S)-pseudo-ginsenoside HQ (S-PHQ) are the main metabolites of (20S)-ginsenoside Rh-2 (Rh-2) in vivo. In this study, we found that Rh-2, R-PHQ, and S-PHQ upregulated the innate and adaptive immune response in cyclophosphamide (CTX) induced-immunocompromised mice as evidenced by the number of leukocytes, cellular immunity, and phagocytosis of macrophages. Spleen T-lymphocyte subpopulations and the serum cytokines level were also balanced in these immunosuppressed mice. Furthermore, co-administration with R-PHQ or S-PHQ did not compromise the antitumor activity of CTX in the hepatoma H22-bearing mice. Treatment with R-PHQ and S-PHQ clearly induced the apoptosis of tumor cells, significantly increased the expression of Bax, and remarkably inhibited the expression of Bcl-2 and vascular endothelial growth factor (VEGF) in H22 tumor tissues. The anti-tumor activity of R-PHQ and S-PHQ could be related to the promotion of tumor apoptosis and inhibition of angiogenesis and may involve the caspase and VEGF signaling pathways. This study provides a theoretical basis for further study on R-PHQ and S-PHQ.

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