Novel genotype of infectious bronchitis virus isolated in China

文献类型： 外文期刊

第一作者： Ma, Tianxin

作者： Ma, Tianxin;Xu, Liwen;Ren, Mengting;Shen, Jie;Han, Zongxi;Sun, Junfeng;Zhao, Yan;Liu, Shengwang

作者机构：

关键词： Infectious bronchitis virus; Genotype; Serotype; Recombination event; Affinity

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2019 年 230 卷

页码：

收录情况： SCI

摘要： Recombination events are known to contribute to the emergence of novel infectious bronchitis virus (IBV) genotypes. In this study, we carried out detailed phylogenetic analysis and sequence comparisons based on 74 complete nucleotide sequences of the IBV S1 gene, including strain 10636/ 16 and 73 representative sequences from each genotype and lineage. The results showed that strain 10636/16 represented a novel genotype, designated as lineage 1 within genotype VII (GVII-1). Further comparative genomic analysis revealed at least two recombination sites that replaced the spike gene in a lineage 18 within genotype I (GI-18)-like virus with an as-yet-unidentified sequence, likely derived from another IBV strain, resulting a novel serotype with a lower affinity to the respiratory tract in chickens. To the best of our knowledge, this provides the first evidence for recombination leading to replacement of the complete spike gene and the emergence of a novel genotype/serotype with a lower affinity to the respiratory tract in chickens comparing to one of its parental virus ck/CH/LGX/ 111119. These results emphasize the importance of limiting exposure to novel IBVs that may serve as a source of genetic material for emerging viruses, as well as the importance of IBV surveillance in chicken flocks.

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