Evaluation and comparison of immunogenicity and cross-protective efficacy of two inactivated cell culture-derived GIIa- and GIIb-genotype porcine epidemic diarrhea virus vaccines in suckling piglets

文献类型： 外文期刊

第一作者： Liu, Xinsheng

作者： Liu, Xinsheng;Zhang, Liping;Zhang, Qiaoling;Zhou, Peng;Fang, Yuzhen;Zhao, Donghong;Feng, Jiaxin;Li, Weiyan;Zhang, Yongguang;Wang, Yonglu;Liu, Xinsheng;Zhang, Liping;Zhang, Qiaoling;Zhou, Peng;Fang, Yuzhen;Zhao, Donghong;Feng, Jiaxin;Li, Weiyan;Zhang, Yongguang;Wang, Yonglu

作者机构：

关键词： Porcine epidemic diarrhea virus; Immunogenicity; Protective efficacy; Inactivated vaccine; Suckling piglets

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2019 年 230 卷

页码：

收录情况： SCI

摘要： Although highly virulent Gil-genotype PEDV strains have become pandemic in the swine population worldwide, little is known about the differences in immunogenicity and cross-protective efficacy between the GIla and GIIb subgenotypes. Hence, in the present study, we vaccinated suckling piglets with GIIa. (CH/HBXT/2018) and Glib (CH/HNPJ/2017) PEDV strain-based inactivated vaccine candidates and compared their immunogenicity and cross-protective efficacy. The results showed that both vaccine candidates induced high levels of PEDV-specific IgG antibodies and IFN-y and reduced the levels of neutralizing antibodies at 21 dpv in suckling piglets. The GIIa-based inactivated vaccine protected all piglets (8/8) against virulent homologous and heterologous virus challenge, while the Glib strain-based inactivated vaccine protected only 2/4 and 1/4 piglets against virulent homologous and heterologous virus challenge, respectively. Furthermore, antibodies against the GIIa and GIIb strains cross-reacted and cross-neutralized both strains in vitro. Taken together, the data presented in this study indicate that GIla strain-based inactivated vaccine candidates are more promising than GIIb-based candidates for the development of an effective vaccine against the current highly virulent pandemic PEDV strains.

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