The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages
文献类型： 外文期刊
第一作者： Pang, Yu
作者： Pang, Yu;Yang, Xiuqin;Pang, Yu;Zhang, Zhaoxia;Chen, Yuntong;Cao, Shinuo;Jia, Honglin
作者机构：
关键词： antioxidation; autophagy; Keap1; Nrf2; p62; ROS; Toxoplasma gondii
期刊名称：PARASITE IMMUNOLOGY （ 影响因子：2.28； 五年影响因子：3.195 ）
ISSN： 0141-9838
年卷期： 2019 年 41 卷 5 期
页码：
收录情况： SCI
摘要： Reactive oxygen species (ROS) produced by oxidases and nonenzymatic sources are important for host defence against intracellular pathogens. In this study, we knocked out the Nrf2 gene in RAW264.7 cells using the CRISPR/Cas9 system and investigated the antioxidant effects of the Nrf2 pathway in the cells stimulated by IFN-gamma and TNF-alpha. The results indicated that the Nrf2 signalling pathway is necessary for maintaining redox homeostasis in activated RAW264.7 cells. Inactivation of Nrf2 impaired parasite growth. We also found that p62 contributes to Nrf2-mediated pathways involved in T gondii infection. These findings suggest that the Nrf2/Keap1 pathway may be targeted to prevent and treat toxoplasmosis.
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