The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages
文献类型： 外文期刊
第一作者： Pang, Yu
作者： Pang, Yu;Yang, Xiuqin;Pang, Yu;Zhang, Zhaoxia;Chen, Yuntong;Cao, Shinuo;Jia, Honglin
作者机构：
关键词： antioxidation; autophagy; Keap1; Nrf2; p62; ROS; Toxoplasma gondii
期刊名称：PARASITE IMMUNOLOGY （ 影响因子：2.28； 五年影响因子：3.195 ）
ISSN： 0141-9838
年卷期： 2019 年 41 卷 5 期
页码：
收录情况： SCI
摘要： Reactive oxygen species (ROS) produced by oxidases and nonenzymatic sources are important for host defence against intracellular pathogens. In this study, we knocked out the Nrf2 gene in RAW264.7 cells using the CRISPR/Cas9 system and investigated the antioxidant effects of the Nrf2 pathway in the cells stimulated by IFN-gamma and TNF-alpha. The results indicated that the Nrf2 signalling pathway is necessary for maintaining redox homeostasis in activated RAW264.7 cells. Inactivation of Nrf2 impaired parasite growth. We also found that p62 contributes to Nrf2-mediated pathways involved in T gondii infection. These findings suggest that the Nrf2/Keap1 pathway may be targeted to prevent and treat toxoplasmosis.
分类号：
- 相关文献
作者其他论文 更多>>
-
N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1
作者：Yu, Mengmeng;Zhang, Yao;Zhang, Li;Wang, Suyan;Liu, Yongzhen;Xu, Zhuangzhuang;Liu, Peng;Chen, Yuntong;Guo, Ru;Meng, Lingzhai;Zhang, Tao;Fan, Wenrui;Qi, Xiaole;Gao, Li;Zhang, Yanping;Cui, Hongyu;Gao, Yulong;Gao, Yulong;Gao, Yulong
关键词：
-
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway
作者：Ye, Guangqiang;Zhang, Zhaoxia;Liu, Xiaohong;Liu, Hongyang;Chen, Weiye;Feng, Chunying;Li, Jiangnan;Zhou, Qiongqiong;Zhao, Dongming;Zhang, Shuai;Chen, Hefeng;Bu, Zhigao;Huang, Li;Weng, Changjiang;Zhang, Zhaoxia;Li, Jiangnan;Huang, Li;Weng, Changjiang
关键词：ASFV; pH240R; ISGs; IFN; JAK-STAT; viral replication
-
OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway
作者：Wang, Suyan;Xu, Zhuangzhuang;Liu, Yongzhen;Yu, Mengmeng;Zhang, Tao;Liu, Peng;Qi, Xiaole;Chen, Yuntong;Meng, Lingzhai;Guo, Ru;Zhang, Li;Fan, Wenrui;Gao, Li;Duan, Yulu;Zhang, Yanping;Cui, Hongyu;Gao, Yulong;Gao, Yulong;Gao, Yulong;Gao, Yulong
关键词：IBDV; OASL; VP2; degradation; autophagy
-
The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs
作者：Yang, Shuo;Yang, Xiuqin;Ma, Hong;Wang, Liang;Wang, Fang;Liu, Di;Xia, Jiqiao;Liu, Dongyu;Mu, Linlin
关键词：cold stress; piglets; ADRB3; beige adipocytes; thermogenesis
-
Characteristics of walnut oil and the residual cake prepared using various pretreatment and extraction methods
作者：Cao, Shinuo;Xiang, Fei;Li, Shanshan;Ma, Xiaojie;Hu, Hui;Guo, Qin;Jiao, Bo;Wang, Qiang;Shi, Aimin;Cao, Shinuo;Wang, Qiang;Shi, Aimin;Agyei, Dominic;Wang, Qiang
关键词：Walnut oil; Walnut protein; Pretreatment; Processing; Functional properties
-
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways
作者：Liu, Xiaohong;Chen, Hefeng;Ye, Guangqiang;Liu, Hongyang;Feng, Chunying;Chen, Weiye;Hu, Liang;Zhou, Qiongqiong;Zhang, Zhaoxia;Li, Jiangnan;Zhang, Xianfeng;He, Xijun;Guan, Yuntao;Wu, Zhengshuang;Zhao, Dongming;Bu, Zhigao;Weng, Changjiang;Huang, Li;Zhang, Zhaoxia;Li, Jiangnan;Weng, Changjiang;Huang, Li
关键词：
-
Comparison of the performance of SAG2, GRA6, and GRA7 for serological diagnosis of Toxoplasma gondii infection in cats
作者：Sabukunze, Serges;Gu, Haorong;Zhao, Lin;Jia, Honglin;Guo, Huanping;Jia, Honglin
关键词：Toxoplasma gondii; SAG2; GRA3; GRA6; GRA7; serodiagnosis; cats
