Hollow mesoporous silica nanoparticles as delivery vehicle of foot-and-mouth disease virus-like particles induce persistent immune responses in guinea pigs

文献类型： 外文期刊

第一作者： Bai, Manyuan

作者： Bai, Manyuan;Dong, Hu;Su, Xin;Jin, Ye;Sun, Shiqi;Guo, Huichen;Bai, Manyuan;Dong, Hu;Su, Xin;Jin, Ye;Sun, Shiqi;Guo, Huichen;Su, Xin;Zhang, Yingpeng;Yang, Yunshang

作者机构：

关键词： foot-and-mouth disease; guinea pigs; hollow mesoporous silicananoparticles; immunization; virus-like particles

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：2.327； 五年影响因子：2.075 ）

ISSN： 0146-6615

年卷期： 2019 年 91 卷 6 期

页码：

收录情况： SCI

摘要： Foot-and-mouth disease (FMD) is an acute and febrile infectious disease, which can cause great economic losses. Virus-like particles (VLPs) as an advantageous antigen can induce significant specific immune response. To improve immunity of VLPs, especially, make it induce persistent immune response, the hollow mesoporous silica nanoparticles (HMSNs) as a potential nano-adjuvant were synthesized and loaded the FMD virus (FMDV) VLPs. They were injected into guinea pigs and the specific immune response was detected. The results confirmed that HMSNs/VLPs can induce persistent humoral immunity with high-level antibody titer for more than three months. HMSNs also improve the T-lymphocyte proliferation and IFN-gamma induced by FMDV VLPs, and provides the ideal protection against FMDV challenge. These consequences indicated that HMSNs were good protein delivery vehicle and potential nano-adjuvant of vaccines.

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