The role of active immunization against inhibin alpha-subunit on testicular development, testosterone concentration and relevant genes expressions in testis, hypothalamus and pituitary glands in Yangzhou goose ganders

文献类型： 外文期刊

第一作者： Akhtar, Muhammad Faheem

作者： Akhtar, Muhammad Faheem;Wei, Quanwei;Shi Zhendan;Shi, Fangxiong;Zhu, Huanxi;Chen, Zhe;Ahmad, Ejaz

作者机构：

关键词： Yangzhou goose; Testis; Gene expression; Inhibin immunization

期刊名称：THERIOGENOLOGY （ 影响因子：2.74； 五年影响因子：2.93 ）

ISSN： 0093-691X

年卷期： 2019 年 128 卷

页码：

收录情况： SCI

摘要： The present study was designed to investigate the potential role of immunization against inhibin on testicular development, plasma testosterone concentration and expression of relevant genes in hypothalamus, pituitary, Leydig and Sertoli cells in Yangzhou ganders. For this purpose, Yangzhou ganders, n = 30 were divided into groups A and B. Group B ganders were actively immunized against inhibin subunit, while group A ganders were immunized with bovine serum albumin (BSA), which served as control. Immunization against inhibin elevated testes weights. In addition, immunization against inhibin elevated GnRH, StAR, CYP11A1 and AMH mRNA transcription expressions as depicted by qRT-PCR. Furthermore, hypothalamic GnRH-1 mRNA expressions were up regulated, while GnIH mRNA transcription expression showed reciprocal expression on day 227. LH-beta mRNA transcription expression remained unaffected. In conclusion, our findings suggest that active immunization against inhibin affect spermatogenesis and testicular development through regulations of hypothalamic, pituitary and testicular genes expressions. (C) 2019 Elsevier Inc. All rights reserved.

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