In-depth Proteome of the Hypopharyngeal Glands of Honeybee Workers Reveals Highly Activated Protein and Energy Metabolism in Priming the Secretion of Royal Jelly

文献类型： 外文期刊

第一作者： Hu, Han

作者： Hu, Han;Bezabih, Gebreamlak;Feng, Mao;Wei, Qiaohong;Zhang, Xufeng;Hu, Fan;Meng, Lifeng;Fang, Yu;Han, Bin;Ma, Chuan;Li, Jianke

作者机构：

期刊名称：MOLECULAR & CELLULAR PROTEOMICS （ 影响因子：5.911； 五年影响因子：5.998 ）

ISSN： 1535-9476

年卷期： 2019 年 18 卷 4 期

页码：

收录情况： SCI

摘要： Royal jelly (RJ) is a secretion of the hypopharyngeal glands (HGs) of honeybee workers. High royal jelly producing bees (RJBs), a stock of honeybees selected from Italian bees (ITBs), have developed a stronger ability to produce RJ than ITBs. However, the mechanism underpinning the high RJ-producing performance in RJBs is still poorly understood. We have comprehensively characterized and compared the proteome across the life span of worker bees between the ITBs and RJBs. Our data uncover distinct molecular landscapes that regulate the gland ontogeny and activity corresponding with age-specific tasks. Nurse bees (NBs) have a well-developed acini morphology and cytoskeleton of secretory cells in HGs to prime the gland activities of RJ secretion. In RJB NBs, pathways involved in protein synthesis and energy metabolism are functionally induced to cement the enhanced RJ secretion compared with ITBs. In behavior-manipulated RJB NBs, the strongly expressed proteins implicated in protein synthesis and energy metabolism further demonstrate their critical roles in the regulation of RJ secretion. Our findings provide a novel understanding of the mechanism consolidating the high RJ-output in RJBs.

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