Parental exposure to 2,2 ',4,4 ' 5-pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish

文献类型： 外文期刊

第一作者： Wu, Luyin

作者： Wu, Luyin;Xie, Huaxiao;Wu, Luyin;Li, Yunfeng;Ru, Huijun;Xie, Huaxiao;Yao, Fan;Ni, Zhaohui;Zhong, Liqiao;Yao, Fan

作者机构：

关键词： PBDEs; Zebrafish; Developmental toxicity; Thyroid disruption; Hypothalamic-pituitary-thyroid-liver (HPTL) axis

期刊名称：TOXICOLOGY AND APPLIED PHARMACOLOGY （ 影响因子：4.219； 五年影响因子：4.302 ）

ISSN： 0041-008X

年卷期： 2019 年 372 卷

页码：

收录情况： SCI

摘要： Although polybrominated diphenyl ethers (PBDEs) are known to disturb thyroid hormone signaling, the mechanisms underlying the effects of 2,2',4,4'5- pentain polybrominated diphenyl ethers (BDE-99) in fish remain unclear. In order to reveal these mechanisms, adult zebrafish (Danio rerio) were exposed to different concentrations of BDE-99 (0, 0.5, 5, or 50 mu g/L) for 28 days and spawned by mating naturally in clean water (without BDE-99). Females exposed to BDE-99 showed significantly lowered thyroxine (T4) levels. Expression of transthyretin (ttr) and uridine diphosphate glucuronosyl transferase (ugtlab) were down-regulated and up-regulated, respectively. Triiodothyronine (T3) levels in the 0.5 mu g/L BDE-99 exposure group was significantly increased. Males showed significantly increased T3 levels, and lowered T4 levels, which were associated with up-regulated and down-regulated expression of deiodinase 2 (deio2) and ugtlab, respectively. Exposure of adult zebrafish to BDE-99 lead to significantly increased T4 in the 0.5 mu g/L BDE-99 exposure group, but in the 50 mu g/L BDE-99 exposure group there was significantly reduced T4 in F1 larvae and altered mRNA transcription in the hypothalamic-pituitary-thyroid-liver (HPTL) axis. The offspring also showed reduced survival rates, and body length and elevated malformation rates. This study is the first in zebrafish to show that parental zebrafish exposure to BDE-99 can lead to developmental toxicity and thyroid disruption in the offspring.

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