A novel phage from periodontal pockets associated with chronic periodontitis

文献类型： 外文期刊

第一作者： Zhang, Yu

作者： Zhang, Yu;Li, Fei;Yu, Tian;Chen, Xi;Feng, Xi-Ping;Shan, Tong-Ling;Zhang, Yu;Li, Fei;Yu, Tian;Chen, Xi;Feng, Xi-Ping;Zhang, Yu;Li, Fei;Yu, Tian;Chen, Xi;Feng, Xi-Ping;Shan, Tong-Ling;Deng, Xu-Tao;Delwart, Eric;Deng, Xu-Tao;Delwart, Eric

作者机构：

关键词： Bacteriophage; Siphovirus; Periodontitis; Viral metagenomics; Case-control study

期刊名称：VIRUS GENES （ 影响因子：2.332； 五年影响因子：2.0 ）

ISSN： 0920-8569

年卷期： 2019 年 55 卷 3 期

页码：

收录情况： SCI

摘要： Bacteriophages often constitute the majority of periodontal viral communities, but phages that infect oral bacteria remain uncharacterized. Here, we present the genetic analysis of the genome of a novel siphovirus, named Siphoviridae_29632, which was isolated from a patient with periodontitis using a viral metagenomics-based approach. Among 43 predicted open reading frames (ORFs) in the genome, the viral genes encoding structural proteins were distinct from the counterparts of other viruses, although a distant homology is shared among viral morphogenesis proteins. A total of 28 predicted coding sequences had significant homology to other known phage ORF sequences. In addition, the prevalence of Siphoviridae_29632 in a cohort of patients with chronic periodontitis was 41.67%, which was significantly higher than that in the healthy group (4.55%, P < 0.001), suggesting that this virus as well as its hosts may contribute to the ecological environment favored for chronic periodontitis.

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