Effect of simvastatin on bovine intramuscular and subcutaneous adipocytes proliferation and gene expression in vitro

文献类型： 外文期刊

第一作者： Jin, Qing

作者： Jin, Qing;Wei, Chen;Zhao, Hong-Bo;Tan, Xiu-Wen;Wan, Fa-Chun;Liu, Gui-Fen;Jin, Qing;Wei, Chen;Tan, Xiu-Wen;Wan, Fa-Chun;Liu, Gui-Fen

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关键词： Simvastatin; cholesterol; gene expression; adipocytes; beef cattle

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： Simvastatin (SIM) is a widely used anticholesterolemic drug that blocks the biosynthesis of cholesterol. However, SIM also has pleiotropic effects on 3-hydroxy-3-methyglutary-CoA reductase (HMGR), cholesteryl ester transfer protein (CETP), and lipoprotein lipase (LPL), which are important genes in the cholesterol biosynthesis and transport processes. We investigated the effects of different concentrations of SIM on the mRNA expression of these genes in bovine intramuscular and subcutaneous adipocytes from the longissimus dorsi muscle and subcutaneous fat tissues of Luxi Yellow cattle. The results showed that SIM treatment showed dose-dependent toxicity on normal adipose cells, but no effect on cell proliferation. SIM decreased HMGR expression in a dose-dependent manner but showed no significant effect on CETP and LPL expression. Thus, SIM may lower the cholesterol content by decreasing the HMGR expression level, but CETP and LPL may be regulated through other mechanisms, which require further investigation.

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