Genetic Mutation Analysis of High and Low IgY Chickens by Capture Sequencing

文献类型： 外文期刊

第一作者： Wang, Qiao

作者： Wang, Qiao;Wang, Fei;Liu, Lu;Li, Qinghe;Liu, Ranran;Zheng, Maiqing;Cui, Huanxian;Wen, Jie;Zhao, Guiping;Wang, Qiao;Wang, Fei;Li, Qinghe;Liu, Ranran;Zheng, Maiqing;Cui, Huanxian;Wen, Jie;Zhao, Guiping;Liu, Lu;Zhao, Guiping

作者机构：

关键词： SNP; Indel; White Leghorn; Beijing-You; IgY level

期刊名称：ANIMALS （ 影响因子：2.752； 五年影响因子：2.942 ）

ISSN： 2076-2615

年卷期： 2019 年 9 卷 5 期

页码：

收录情况： SCI

摘要： Based on the results of our previous genome-wide association study (GWAS), a comprehensive analysis on single nucleotide polymorphisms (SNPs) was performed on White Leghorn and Beijing-You chickens with high and low IgY levels in defined genomic regions using the capture-sequencing approach. High and low IgY chickens showed substantial genetic variations. In total, more than 30,000 SNPs were found in all four chicken groups, among which 1045 were non-synonymous mutations resulting in amino acids alterations. In total, 23,309 Indels were identified. Among the 1169 Indels that were found only in Beijing-You chickens, 702 were shared between high and low IgY chickens compared with the reference genome. There were 1016 Indels specific to the White Leghorn chickens, among which 188 were high IgY-specific, 134 were low IgY-specific and 694 were shared between the high and low IgY chicken lines. Many genetic mutations were located in the regulatory regions of important immunomodulatory genes, including TAP1, TAP2 and BF1. Our findings provide an in-depth understanding of genetic mutations in chicken microchromosomes.

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