Determination of Chlorpyrifos and Its Main Metabolite in Tea by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Yin Peng

作者： Yin Peng;Guo Gui-Yi;Yin Peng;Dai Jin-Xia;Zhu Li;Gao Guan-Wei;Chen Hong-Ping;Liu Xin;Dai Jin-Xia;Zhu Li;Gao Guan-Wei;Chen Hong-Ping;Liu Xin;Chen Hong-Ping;Liu Xin

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关键词： Tea; Chlorpyrifos; 3, 5, 6-Trichloro-2-pyridinol; Ultra-high performance liquid chromatography coupled with tandem mass spectrometry

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）

ISSN： 0253-3820

年卷期： 2019 年 47 卷 2 期

页码：

收录情况： SCI

摘要： A sensitive method was developed for simultaneous determination of chlorpyrifos ( CPF) and its main metabolite 3,5,6-trichloro-2-pyridinol ( TCP) in tea samples by QuEChERS and ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Tea samples were extracted with acidic acetonitrile ( containing 5% acetic acid), and cleaned up by the mixture of adsorbents containing 100 mg of graphitized carbon black ( GCB) and 200 mg of C-18. The extracts were diluted with deionized water equally in volume prior to instrumental analysis. Scheduled multiple reaction monitoring in positive ion mode was applied to detection of chlorpyrifos and selected ion recording in negative mode was applied to detection of TCP. The matrix-matched internal standard method was used for quantification. The results showed that the method provided linear ranges from 0. 4 to 400 mu g/kg and 0. 4 to 80 mu g/kg for CPF and TCP respectively with the correlation coefficients of larger than 0. 99. The limits of detection (S/N= 3) were 0. 06 mu g/kg for CPF and 0.04-0.08 mu g/kg for TCP, while the limits of quantification ( S/N= 10) were 0. 20 mu g/kg for CPF and 0. 14-0.26 mu g/kg for TCP. The recoveries were ranged from 93. 9% to 111. 4% for CPF and 92. 4% to 118.4% for TCP respectively with the relative standard deviations ( RSD, n = 6) of 3. 2% -11. 1%. This method was sensitive, rapid, simple and had good reproducibility, indicating that it was suitable for simultaneous determination of CPF and TCP in tea samples.

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