Genetic basis of ruminant headgear and rapid antler regeneration

文献类型： 外文期刊

第一作者： Wang, Yu

作者： Wang, Yu;Wang, Nini;Zhao, Yue;Pan, Xiangyu;Zheng, Zhuqing;Dou, Mingle;Peng, Shujun;Liu, Jing;Li, Ming;Song, Chengchuang;Zhao, Chen;Jiang, Yu;Zhang, Chenzhou;Chen, Xianqing;Wang, Kun;Liu, Chang;Lin, Zeshan;Chen, Lei;Zhu, Wenbo;Wang, Wen;Qiu, Qiang;Li, Zhipeng;Li, Guangyu;Heller, Rasmus;Liu, Rong;Dai, Xueqin;Chen, Ceshi;Liu, Rong;Dai, Xueqin;Chen, Ceshi;Zhang, Guojie;Wang, Wen;Han, Jiangang;Jiang, Lin;Hao, Fei;Yang, Hui;Zheng, Chengli;Wang, Jianming;Hu, Shengwei;Li, Cunyuan;Liu, Mingjun;Sonstegard, Tad S.;Zhang, Guojie;Zhang, Guojie;Wang, Wen;Zhang, Guojie

作者机构：

期刊名称：SCIENCE （ 影响因子：47.728； 五年影响因子：51.433 ）

ISSN： 0036-8075

年卷期： 2019 年 364 卷 6446 期

页码：

收录情况： SCI

摘要： Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

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