A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat

文献类型： 外文期刊

第一作者： Su, Zhenqi

作者： Su, Zhenqi;Chen, Hui;Wang, Shan;Ma, Hongxiang;Cai, Shibin;Liu, Dongtao;Zhang, Dadong;Li, Tao;Bai, Guihua;Su, Zhenqi;Bernardo, Amy;Tian, Bin;Trick, Harold;Ma, Hongxiang;Cai, Shibin;Li, Tao;St Amand, Paul;Bai, Guihua;Yu, Jianming;Zhang, Zengyan

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：38.33； 五年影响因子：36.431 ）

ISSN： 1061-4036

年卷期： 2019 年 51 卷 7 期

页码：

收录情况： SCI

摘要： Fusarium head blight (FHB), which is mainly caused by Fusarium graminearum, is a destructive wheat disease that threatens global wheat production. Fhb1, a quantitative trait locus discovered in Chinese germplasm, provides the most stable and the largest effect on FHB resistance in wheat. Here we show that TaHRC, a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1-mediated resistance to FHB. We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. Identical sequences of the TaHRC-R allele in diverse accessions indicate that Fhb1 had a single origin, and phylogenetic and haplotype analyses suggest that the TaHRC-R allele most likely originated from a line carrying the Dahongpao haplotype. This discovery opens a new avenue to improve FHB resistance in wheat, and possibly in other cereal crops, by manipulating TaHRC sequence through bioengineering approaches.

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