Design and Optimization of Thioglycosyl-naphthalimides as Efficient Inhibitors Against Human O-GlcNAcase

文献类型： 外文期刊

第一作者： Dong, Lili

作者： Dong, Lili;Wu, Renjie;Lu, Huizhe;Zhang, Jianjun;Chen, Wei;Yang, Qing

作者机构：

关键词： thioglycosyl-naphthalimides; ureido glycosides; beta-N-acetylhexosaminidases; human O-GlcNAcase; inhibitors; molecular docking and MD simulations

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）

ISSN： 2296-2646

年卷期： 2019 年 7 卷

页码：

收录情况： SCI

摘要： beta-N-acetylhexosaminidases represent an important class of exoglycosidases and have emerged as the promising targets for drug and pesticide discovery. Among these, human O-GlcNAcase (hOGA) has been reported to be closely linked to several diseases such as Alzheimer's disease, diabetes, and cancer. Potent hOGA inhibitors with high selectivity are therefore of great significance for the regulation of the corresponding physiological processes. In this study, several classes of novel and readily available thioglycosyl-naphthalimides bearing the amide linker were designed and synthesized. To investigate their potency and selectivity, the inhibitory efficiencies toward hOGA and human beta-N-acetylhexosaminidase B (HsHexB) were assayed. Especially, compounds 10a (K-i = 0.61 mu M) and 16l (K-i = 0.72 mu M) exhibited excellent inhibitory potency against hOGA and high selectivity (HsHexB, K-i > 100 mu M). In addition, during the preparation of these thioglycosyl-naphthalimides, a new practical method was developed for the synthesis of ureido glycosides from trichloroethyl carbamates at room temperature and normal pressure without catalyst. Furthermore, the possible binding modes of hOGA with 10a, 10d, and 16j were studied using molecular docking and molecular dynamics simulations to explore the molecular basis for the potency of these thioglycosides. This work present here provides useful clues for the further structural optimization toward hOGA.

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