Advances in understanding insect chitin biosynthesis

文献类型： 外文期刊

第一作者： Yu, Ailing

作者： Yu, Ailing;Yang, Qing;Yu, Ailing;Yang, Qing;Beck, Marius;Merzendorfer, Hans

作者机构：

关键词： Chitin biosynthesis; Insect chitin synthase; Auxiliary proteins

期刊名称：INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY （ 影响因子：3.8； 五年影响因子：4.4 ）

ISSN： 0965-1748

年卷期： 2024 年 164 卷

页码：

收录情况： SCI

摘要： Chitin, a natural polymer of N-acetylglucosamine chains, is a principal component of the apical extracellular matrix in arthropods. Chitin microfibrils serve as structural components of natural biocomposites present in the extracellular matrix of a variety of invertebrates including sponges, molluscs, nematodes, fungi and arthropods. In this review, we summarize the frontier advances of insect chitin synthesis. More specifically, we focus on the chitin synthase (CHS), which catalyzes the key biosynthesis step. CHS is also known as an attractive insecticidal target in that this enzyme is absent in mammals, birds or plants. As no insect chitin synthase structure have been reported so far, we review recent studies on glycosyltransferase domain structures derived from fungi and oomycetes, which are conserved in CHS from all species containing chitin. Auxiliary proteins, which coordinate with CHS in chitin biosynthesis and assembly, are also discussed.

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