Self-assembly of peptide nanocapsules by a solvent concentration gradient

文献类型： 外文期刊

第一作者： Li, Haopeng

作者： Li, Haopeng;Han, Xiao;Miserez, Ali;Yu, Jing;Li, Haopeng;Qi, Huitang;Yuan, Fenghou;Liu, Tian;Qian, Xuliang;Zou, Guijin;Gao, Huajian;Mohanram, Harini;Zou, Guijin;Gao, Huajian;Miserez, Ali;Yang, Qing;Yang, Qing;Gao, Huajian;Yu, Jing

作者机构：

期刊名称：NATURE NANOTECHNOLOGY （ 影响因子：38.3； 五年影响因子：39.9 ）

ISSN： 1748-3387

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Biological systems can create materials with intricate structures and specialized functions. In comparison, precise control of structures in human-made materials has been challenging. Here we report on insect cuticle peptides that spontaneously form nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from the mixing of water and acetone drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is found to be the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards simple generation of drug delivery systems based on peptide nanocapsules. Biobased materials are of interest for many applications. Here the authors report insect-derived peptides that self-assemble into hollow nanocapsules through a gradient-driven, single-step, solvent exchange process, enabling the encapsulation of diverse cargoes with potential for drug delivery applications.

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