Role of apoptosis in Duck Tembusu virus infection of duckling brains in vivo

文献类型： 外文期刊

第一作者： Yang, Sheng

作者： Yang, Sheng;Wu, Jingxian;Huang, Yufei;Zhang, Yafei;Shi, Yonghong;Yang, Ping;Chen, Qiusheng;Shi, Yonghong

作者机构：

关键词： Duck Tembusu virus; brain; apoptosis

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

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年卷期： 2022 年 101 卷 3 期

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收录情况： SCI

摘要： The Duck Tembusu virus (DTMUV) is a novel flavivirus that occurs mainly in poultry. DTMUV infection can cause common neurological symptoms in ducklings, but the pathogenesis of DTMUV has not been elucidated yet. In this study, a DTMUV-infected duckling model was constructed to investigate the apoptosis in the duckling brains. After DTMUV infection, apoptotic cells were observed by transmission electron microscopy. It was found that the abundances of apoptosis-related genes and proteins were not obviously changed in the early stage of infection but significantly changed in the middle and late stages of the disease. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay staining results were also consistent with the above phenomena. Interestingly, although apoptosis occurred in the duckling brains infected by DTMUV, some antiapoptotic genes in the brain increased in varying degrees. In conclusion, DTMUV infection could induce apoptosis in ducklings' brains, and the occurrence of apoptosis was accompanied by the virus infection process with certain regularity. This study provides a scientific basis for elucidating the apoptotic mechanism of brain lesions induced by DTMUV infection.

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