Efficacy of Chlorogenic Acid in Treating Tripterygium Glycoside-Induced Asthenozoospermia in Rats and Its Possible Mechanisms

文献类型： 外文期刊

第一作者： Chen, Long

作者： Chen, Long;Bello-Onaghise, God'spower;Li, Shunda;Zhang, Yu;Qu, Qianwei;Li, Yanhua;Bello-Onaghise, God'spower;Chen, Mo;Wang, Haoran

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关键词： Tripterygium glucosides; asthenozoospermia; chlorogenic acid; antioxidants; oxidative stress; network pharmacology

期刊名称：VETERINARY SCIENCES （ 影响因子：2.3； 五年影响因子：2.4 ）

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年卷期： 2025 年 12 卷 1 期

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收录情况： SCI

摘要： Tripterygium glycoside (TG) is a potent medication for treating autoimmune diseases. However, it has also been associated with toxic effects on testicular tissues. This study evaluated the antioxidant potential of chlorogenic acid (CGA) in protecting testicular tissues in rats with TG-induced asthenozoospermia (AZS). A total of 45 6-week-old Sprague-Dawley rats were divided into a control (10 rats) and a TG group (35 rats). The control group received 10 mL of deionized water, while the TG group received 40 mg/kg TG/i.g./28 d to establish the asthenozoospermia (AZS) model as assessed by sacrificing five rats from each group. The remaining 5 and 30 rats were divided into control, TG + LC, TG, TG + CGA-L, TG + CGA-M, TG + CGA-H groups, n = 5. The control and TG groups received 10 mL of deionized water. TG + LC received L-carnitine (0.2 g/kg/d), and the TG + CGA-L, TG + CGA-M, and TG + CGA-H groups received 25 mg/kg, 50 mg/kg, and 100 mg/kg of CGA, respectively, via gavage for 28 days. From the results, TG effectively induced asthenozoospermia in the rats through oxidative damage to testicular tissues, significantly increasing ROS and MDA along with hormonal and physio-biochemical dysfunction. Simultaneously, CGA treatment ameliorated the toxicity of TG.

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